That Lyman mould is the very first one I bought way back in the 60's & it has always shot well for me in many, many different 38's & 357's. You don't say what you're sizing your bullets to, or what size your cylinder throats are, you might look there for the problem. I've taken a lot of small game, hundreds, maybe thousands of ground squirrels using 5.2 grs of Unique in 38 special cases with the above bullet. Also a couple of deer although I like using bigger calibers for big game. I also took my one & only Mountain Lion with that bullet, up close & personal!
Check those throats.

Dick