Thanks for the replies, gentlemen.
I have to admit to being lazy...I know the things to check, but casting has always been an easy thing and I never had any trouble with accuracy before. I guess I was fishing for non-existent common knowledge to the effect of "the 358429 just won't work in an old Blackhawk
because...I am
sizing lubing on a 450 using a .358" sizing die and White Label 50/50 lube. I removed the cylinder from my revolver and inserted bullets as cast into the throats, and I got a light interference fit on all of the chambers. It's hard to say exactly what my alloy is because it is a batch that has been evolving since the early 90s, but I can say it has yielded good results with other bullets in its most recent iteration. I would estimate I'm running about 3% tin and about 2.5% antimony. I do homogenize the entire batch every time I add to it.
I rolled some of the bullets as cast across the my benchtop and could see no oddities.
I will go back and try the 11.0 grains of 2400 suggestion. That seems like a pretty light load that doesn't burn too clean, but I do happen to have stuff to clean guns and don't mind if they get dirty...within reason, of course.
Thanks again for the comments!