Working against the Dasher are it’s shorter barrel life, rapidly eroding throat, and chasing tune.
Not sure where that's coming from......
The last Dasher barrel I took off my 1K BR gun had 2600 rounds through it. Never once did I adjust the original load of Varget, running 105 VLD's at 3080, besides adjusting the seater occasionally. In fact, I've never changed any Dasher load after initial load development.