22 Creed or 22/250 AI are hell on wheels with:

60g Nosler partitons-3700 fps
62g ttsx
62g Speer Gold DOT with bonded core
55g Speer Gold Dots-4000 fps
55g Hornady Sp

std 22/250 with 60g partitions are wicked ugly on deer and hogs with a muzzle velocity of 3500 fps. Destruction on an animal is about like a 300 wm shooting a 150g at 3300.

If you were going longer range:

75g Speer gold dot
80g Hornday
88g Hornady

Impact velocity with a good bullet is a deadly combo. Very little recoil seals the deal on accurate shot placement. Tremendous impact velocity, causes incredible internal organ damage..you just have to see this for yourself how fast the animals collapse.

For long range, a 22-6 Rem AI with 80g Hornady A max at 3700 will kill all deer of any size, Very little recoil!

When you like flat shooting with little recoil, instant kill, above are some answers that will just shock you. For guys sticking to just factory rifles, the 22/250 .

https://www.impactguns.com/rifle-am...60-gr-20box-10case-029465096724-p22250g/

Heart and lungs look like something poured out of a Soup can when shot with one of these rounds.