Yes, twist rate would be my first concern. I am a big fan of the 60 gr bullet in my 22-250s, and now a 22-243AI.
My favorite bullet in 22 caliber is the Hornady 60 gr spire point. And it has shot well at 3650 to 3700 fps in several 14 inch ROT barrels. But the Nosler 60 gr ballistic tip tumbled from the same barrel and same powder charge.
