Thanks for the input and discussion!
Went thru my ammo inventory today, and I have 75 rounds of loaded .375 Ruger ammo with 270 gr. Barnes TSX bullets. Last time I used this ammo was in Argentina, on a successful Asian Water Buff hunt.
The only one of these 270 gr. bullets I have ever recovered was from a Nilgai bull, taken at around 200 yards. Bull went down immediately. Anyway, probably a good round for buffalo, and a good excuse to get the .375 out of the gun safe and back hunting again. I considered also taking my .454 Casull handgun on the hunt, but I simply will not have the time to get in the practice necessary to be confident in shot placement.
