Assuming this is a ranch hunt. Grocery shopping with a rifle. Shot placement trumps caliber as already stated. Took a bison cow a few years back. 7mm08 160 grain accubond. Neck and skull junction dropped where she stood. Rancher shoots his meat bison with a 17 remington. Waits for the perfect shot in the ear hole.
Find out what shots the ranch wants you taking. Some will insist on head shots. Others don't trust peoples shooting abilities and want body shots. If they want body shots then I would go large caliber and tough bullet. Otherwise whatever caliber and rifle combo you would use for whitetails, that you can shoot the most accurately, for headshots.
