I shot a good Bison with my 375 Ruger and the 260gr Partition bullet. First shot was broadside at 125yds and the bullet caught him just behind the shoulder. Upon impact the bull didn't even flinch. He walked a few steps and then turned around (180 deg) presenting me with another broadside shot. Boom …. and the second bullet also hit him just behind the shoulder. Given a few seconds more and he just tipped over dead. Both bullets had expanded into perfect mushrooms and were caught in the off-side hide, one on each side.

I think if I hunt them again I'll use the 270 TSX bullet and see if it exits.

One thing for sure is that buffalo can soak up a lot of lead.