FWIW, my younger brother uses standard cup and core 150 grain soft points. They kill deer dead right there if placed in an appropriate place. His handloads are going at about 2850 fps at the muzzle.
I use the same bullets in a .300 Savage. My handloads are going about 2600 fps. Same result.
That being said, almost any reasonably well constructed bullet of from 135-180 grains will kill a PA whitetail if placed appropriately and none of them will do the job if the shot is in the wrong place. Pick what you are comfortable with and shoot straight. Good luck on your hunt.
