Easy choice for me - I hated loading for 20 caliber cartridges I can only imagine what a pain it must be trying to handle those tiny 17 caliber bullets.
I have a 17 HMR that I use on gophers out to 150-175 yds, for longer shots I pull out my 223. My local Ranch Supply store usually has Hornady 17 HMR ammo priced at $8.99 per box of 50 so everytime I am near there I pick up a couple of boxes, it doesn't take long to lay in a good supply before long doing it that way, and also the out of pocket price is not as noticable as laying out the money for a full case at a time.
I love my 22's LR's for gophers but I find myself using the 17 HMR a lot more than I ever thought I would.
drover