A guy I used to work and hunt with sometimes came across a good deal on a Ruger 77 varmint model in 25-06 in the late 90's. He was bound and determined to take it to the area of Jordan Mt. on a mule deer hunt. I asked him if he thought it might be a touch heavy for such a hunt and he scoughed at me. He is an ex Marine who does triathlons and wouldn't be denied. He shot a 250lb Mule deer buck at a laser ranged 352 yards with it. He hand loaded some 120 grain partitions for it. Not sure the load or velocity, but I do know he got complete penetration through the ribs and the buck dropped in his tracks. His hunting partner on that trip shot a similar buck at 358 yards with a 30-06 and 180 grain Winchester Failsafe ammo. Same results.
Ron
