Yes. The caliber specific reticle has been built upon a specified bullet grain, BC, & velocity. Additionally, if the scope is SFP, the holdover marks are only "true" at one magnification power, usually the highest, but not always. I have a couple of different scopes with a bullet drop compensating reticle and while they are not true to even 100 yard increments, most are pretty close. For instance, according to the Meopta ballistics calculator, with my BDC scope on my .270 shooting my 165 grain load, the third hash mark (nominally 300 yards) is actually 306 yards. That is assuming I have the scope set at the highest power. A quick range check showed it was fairly close, but if I change hunting loads, all that goes out the window.
