I have had both. I am in the 338-06 camp and currently have two, with another on the way.
I like the better selection of bullets for the 338 caliber. On paper the 338-06 has slight advantage.
180's have worked great for deer, 200-210's have worked great on antelope, deer, and elk. Have never used the 160's or heavier than 210's on game. Can't imagine them not working.
I have used a 210gr TSX quite a bit at 2800 plus and feel very confident that it will handle almost everything the planet has to hunt with a couple of exceptions. I feel that it might be a little too hard for deer sized game. But it works. If/when I go back to Africa, it will be with a 338-06 and 210gr TSX's.
With that being said, hand me either one for hunting and I would not have any issues.
