I'm partial to my Les Baer Premier II with the 1.5" 50 yard guarantee and the .7" 50 yard proof target. Now, if only I could shoot that good! My Kimber Stainless Classic is nice and accurate. Now that I put the 460 Roland kit back in it, even more fun. The Bisley Blackhawk convertible makes for easy shooting with the ACP cylinder due to it's heft and my M&P 45's in full size, Compact and Shield can be very enjoyable, too. I prefer the Compact of that threesome. Then there's the 220........always. Speaking of always, I will always wish I had my other Kimbers back.
All in all, I think a 1911 in 45ACP with a Roland and a .22 kit waiting in the wings, would be as close to a do anything handgun as you could get.