Yes, especially with lead bullets, but jacketed bullets benefit too. I agree, the make is probably down the list.
Thread choke also hinders some production guns and has become more prominent as barrels are no longer pinned or fire tightened (think left hand twist).

Timing, forcing cone shape and finish, end shake all add up.
Freedom, MRI and many custom makers generally make dimensions about perfect; the Python definitely is not in their class in regards to throats for sure.