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For lighter gun old S&W Night Guard series is worth a look. They came in .357, .44, 10mm. They had two piece barrel, lock, and MIM parts meaning older guys with lots of money may pass giving better price for more needly gunmen.
The NG 310 was 10mm/40S&W and the 325 was 45 ACP. I don't know how much your hand on the injured side is effected but the moonclips for both of those make a reload easier. They are fairly light so shooting one handed will be peppy but possible.
I'm not a big revolver cc guy for the "main" gun, nothing wrong with it but I prefer an auto. Still, I do like to carry the 310 w/40S&W in a Milt Sparks PMK (
https://www.miltsparks.com/products-pmk.php) with a double speed loader pouch that will hold 2 moon clips in each pouch....that's 24 rounds + what's in the gun.
