If I only had one good hand I think I'd stick with a semiauto with a big magazine, and hopefully that would minimize if not eliminate the need for any manipulations.
I must be missing something because I completely agree with Rufus. Don't see how a revolver solves any problem here. Actually the semiauto with a double stack mag makes more sense than ever if you're limited on reload ability and one hand use, outside of the possibility of clearing a jam. I'd Glock it but that's just me. Your decision certainly.
Glock is easy to shoot and maintain. One can install tall supresor-style sights and use those against surfaces to charge the gun. I can shoot my Glock with one hand w/o problems. The recoil with standard 9x19 ammo is same as Soviet Makarov, no issues.
If one wants the smallest .38 Special revolver S&W made a run for Japanese PD. These had alloy J-frame, short barrel, steel cylinder, and DAO trigger w/o hammer spur. The over-runs were available on American market.
