North61,
You are right on. When my guide friend and I went out to flush a bison from a near by water hole, we used cover and got within 50 yards before it broke and ran left to right . I put a 450 grain Kodiak FMJ through both shoulders and it dropped like a metal target. Did we go pose for pix? Heck no, I levered another one of our African DG rounds in my 45-90 and slowly approached close enough to see it was still alive, and then I put another 450 grain Kodiak at 2150 fps into its heart. Then,it gave up the ghost and passed on. We were still cautious to give it an eye poke before relaxing. Any mature bison could kill a hunter just by running over him trying to escape, much less an injured mad one trying to get even.
[Linked Image from jpgbox.com]
BTW, that load shot through the bison just as it had multiple Cape Buff in Africa. Carrying a proven rifle cartridge combo does a lot for a hunters confidence. And for kills per shot record.

CRS, NRA Benefactor Life Member, Whittington Center, TSRA, DWWC, DRSS
Android Reloading Ballistics App at http://www.xplat.net/