I have found them to be very accurate in all of 6.5's. Out of my 260's and 260 AI's they are explosive for deer in ,my opinion. Out of my 6.5 Grendel I would think they would work with proper shot placement. Velocity is 2850 out of the Grendel. At 3400 and above they are very destructive on coyotes. IMR 4064 in the 260's and AI's. Benchmark in the Grendels.