Ruger Redhawk Alaskan w/ 2” barrel
As others are saying, run 300's. If you handloaded, there might be better options, but a 300gr cast bullet at 1000fps+ is going to do the job. It isn't speed that allows them to work so well; it is momentum. Buy enough so you can run several cylinders beforehand, to make sure they shoot where they should, that they don't back out of the case and tie up your cylinder, and that you can handle the recoil effectively for follow-up shots.