My favorite .22 revolver is the M18 .22 Combat Masterpiece. I've had one since 1982/83 that has had at least 10K rounds fired and is still as tight as when new.

I bought mine as the understudy for my M19 and later M66.

EDIT: I have owned a variety of J-frame Smiths, but they never fit my hand right, so they went on down the road. I have been very pleased with the S&W clones from Rossi, the 511, 515, and 518. They use the same medium size frame as the 720 and 971, which seems to me to be sized somewhere between the J and K frame Smiths. Rossi also offered larger, "target" , grips for those revolvers that fits my hand without being too bulky.

The Rossis will never be Smiths, but they are stainless, so they are more useful to me when the weather is hot/humid and the potential for dripping salty sweat on blued CM and causing unwanted rust is present.