I used to have a fixed 6x on one of my 270's and gave it up for a fixed 4x to increase my FOV. I have no trouble hitting the 12" plate at 400 yards with a fixed 4x. No dialing. No fancy reticle. Just sending a lot rounds down range each year from my rifles.

Unless you're shooting consistently beyond 400 yards there is no advantage to 10x on a big game rifle. If you're consistently shooting at big game beyond 400 yards, get closer.