I've had five different .280AIs, over the years, and there are a number of powders that have worked really well with bullets ranging from 120 - 162 grains. The powders that gave me consistently good results (in all of my rifles) were: IMR 4831, H4831, H4831SC, RL17, RL22, and N165.
The current .280AI loves RL23, as well. I don't think I ever tried in my previous rifles.
I have some RL26 and IMR 7828SSC, that I'd like to try, and I never really gave Ramshot Hunter a solid look. It's good to have options!