I carried a 7RM with 175 Nosler partitions as a fishing rifle while I guided in Alaska, now if I was paying big money to hunt them the 375 would get the nod.

Back to the 280 AI get some R23 or 7977 if you can and get a big jug

I would not have the least reservation on using the 280 AI with any premium 160 or 175 on interior grizzly's.