Well...the way you structured question...I believe you know the answer.

The .250-3000 Savage is one of the best deer cartridges made and even off the shelf run of the mill bullets will likely shoot good (inherently accurate as well) and kill deer well.

The .223 Remington can be made into an acceptable whitetail cartridge.

Both rifles loaded as in the OP...the .250 still has the edge for odd angle shots on a big buck. Core-lokts are no slouches on deer.

Last edited by ledvm; 01/23/21.