Really depends on how well that 100gr CoreLokt matches the .250. A person would have to have actually used both plenty of times to answer. 6.5G looks like .250 Sav on paper. 6.5G is definitely better than .223 for blood trails, but it's not using the same bullets.
I would not use premium bullets in the .223. 62gr Fusion makes a nice exit hole that lets the blood out down the trail and holds up plenty well for high shoulder shots.
