I have a few of the same choices as have been mentioned here, several in fact.
But I have in bound, a Smith & Wesson model 25-7 that may become my “1”. For those not familiar, that is an N frame, 5” barreled, non fluted cylinder 6 shot revolver in 45 Colt.
I believe it will cover a lot of issues..

Its not always easy to do the right thing, But it is always the right thing to do.