I choose two rifles to hunt with.

Get em both ready and shoot em enough to be comfortable in my hands. ONe is what i choose to hunt with and the other is the back up. Most of my deer hunting is from a stand in brush country.
This last year my rifle out the door was a sporterized Mauser in 7 x 57.
The back up was a pre-64 Model 70 in 270, which i enjoy too much to let it be a Closet Queen.

A few times i switched to the back up in the middle of the deer season. Guys in the crew gave me chit for it. So i told em..."hey, in baseball sometimes you change pitchers during the game.' And sometimes i took a deer with the back up.

Some years ago we had a good snow fall and the guys volunteered me to open some trails with my snowshoes. For that i brought out the Savage 99 featherweight in 300 Savage.

If I have em I use em.