I can't imagine a 6.5 PRC and a good bullet not being enough for about any thing in North America. If I was regularly bumping brown and grizzly bears up close or poking at elk at 500 plus yards then some thing bigger would be my choice. Which is why here in Alaska I usually have my .338 or 30-06 in my hands. I have never in 55 years shot out to 500 yards at game and probably never will, except at the range.