If you've been on a good p-dog hunt, you know the feeling at the end of the day. Headache from eye squint as well as from the muzzle blast. You're also getting bombarded by the sun and the wind usually. I'm talking a full day here. This is where the .223s and smaller shine. When you get into large bolt face stuff, it's going to wear you down. No, a .22-250 doesn't have much recoil. However, the cumulative effect of fatigue will take you off of your game.