Just work up to the listed Ramshot maximums--but like Charlie, I've generally found that magnum primers improve accuracy with Big Game a LOT, even in relatively small cartridges like the .308.
The first cartridge I used it in, over 20 years ago, was the .220 Swift. With standard primers 3-shot groups ran around 1-1/2" at 100 yards. With Federal 215s they shrank to 1/2".
