Interesting choice:
A more powerful single shot rifle, or a less powerful bolt action repeater...
I know you really like that 300 H&H, but... I'd be real tempted to use the rifle I was most confident with.
BTW, in .308 Win, I've never used the 150 Interlock, but have had stellar results on game with the 165 grain Nosler Ballistic Tip.
Regards, Guy