The handgun chamberings lobbing subsonic and heavy for caliber bullets are going to require the appropriate sight. You're gonna need to dial or have a rock a solid BDC type reticle with good data for both.
Same for the .300 Blackout which I think would be the best option if you have an appropriate suppressor. The notion that bullets won't open at the subsonic speeds is archaic. All the major manufacturers have produced BO specific bullets and they work. They work very, very well.
