I only have an example of one, but was not impressed when I saw a cow elk killed with a 243. Actually kind of unnerving experience.
mmmm.........I have a pair of 243's that so far have accounted for 14 elk. Mostly in the hands of youngsters--out to ~375 yds. One elk lived just long enough to be shot a second time, the rest were one shot and done.
100g Partiition--it's all in the bullet, cartridge doesn't matter much these days.