Ben East wrote a story called "The Last Shot" in which he described grazing a polar bear with shot no. 1, missing the really angry, charging bear with nos. 2-4, and nailing it between the eyes at very close range with no. 5. Good thing he had a Savage 99 instead of a 4-shot magnum.

I have tried loading all six, and can do it by loading five, closing the bolt enough to hold them down, inserting the sixth round part-way into the chamber, and closing the bolt. If I ever hunt bear, I'll do it in the field.