I was crossing a small creek last week and saw a cottonmouth about 25 yards off. His head was behind some brush so I aimed the 22 mag at his middle and fired. Dang thing went under water and reappeared about 10 feet from me. Then he came at me and I hit him with 2 loads of 44 Special snake shot from my GP100. Fight ended with his head about 3 inches from my foot.
Then I shot a second smaller one with the 22 mag rifle that had been watching the show from the opposite bank. 22 mag works better on the head shots.
Dang I really hate the snakes when it's over 100 out and too hot for snake boots!