I knew a guy once. Big-ass Eskimo, 6'3, 220# , bully, and all-round douche. He beat the chit out of a nice old guy, 2/3 his size, also an Eskimo. When Lazzarus came back for round 2, Gus shot him once with that little (Freedom Arms? ).22 Derringer. That little .22 bounced around awhile inside the rib cage, getting several vital organs- Lazzie made it about 30 yards out the door. No, he didn't come back from the dead.
Good riddance too. Gus had to leave the village for awhile for his own safety. All asswholes have relatives who think the a-hole (once he's dead) was the finest kind ever... . Just the way of the village factions and rivalries. See it with the blacks too. White trash just seem to shrug it off....
I've a couple .22 semi-auto handguns.
As a defensive weapon, I would choose hollow points and plan on using all 10.
If you can't shoot 'em with something big, shoot 'em lots....
I'd prefer my Python, tho I find it rather clumsy. Hey, for the $150 I paid for it, I'll deal with it.
Probably should buy a Glock.....
