Dennis,
I've used H 414 in the 22.250 with a fast twist and the 75 A Max, 80 gr A Max and 75 BTHP...
yet even tho the velocity spread was the highest of any load tested, the most accurate load used H 414, from 100 yds out to 400 yds.
with ANY of the three bullets...
I tripped over at a later point tho... the fastest velocity and accuracy combination with those bullets turned out to be 33.5 grains of 4064, which gave an MV of 3350 fps out of a 24 inch barrel from Pac Nor, 1 in 7 twist, Stainless barrel.
Don't know if you remember when we had the Campfire Get Together in Texas at Ed Too Many Letters place, we had a long distance shoot. you won that one, until they found one target that I hadn't put my name on.. my group was the smallest. I was shooting that 22.250 with the 1 in 7 Twist Pac Nor barrel on a Ruger 77 Mk 2 action, and my load was the one above... 33.5 grains of IMR 4064 with a 75 grain BTHP....
So that should attest to its accuracy potential.