I started using them in milder rounds about 12 years ago. I sought out cartridges that would push the 140 6.5 vld at 2600-2950 fps. I've had great luck and due to the high bc I have long range velocity retention that insures expansion.

Anxious to use the 6/45 I just built to shoot 95 grain vld bullets at about 2550 fps. Going to test that one for expansion soon hopefully to see how it does. If I shot stuff that was going over 3000 fps I'd try other bullets probably.