I think in a 6.5x284, 6.5-06, 280 rem, ect., under 400 yards or so they will hammer at those velocities, heck maybe even 500, but when you ramp up the powder and case volume those bergers do weird stuff inside 200. Just like I was talking about in another thread. My experience shows they don't open if you don't hit bone. But that's just one person. Now in say a 7 rum you run the 180, I'll bet you money, marbles, and chalk that bullet blows throw a deer at 150 to 200 yards and you'll be tracking. Run a 140 in it and you'll have bang flops. But, there will be some damage. It's all about finding the sweet spot. Some bullets work for some people better than others. But as far as damage goes, there is only one classification of dead.