We keep a 45 Colt M94 Trapper at our remote camp, handy bear gun....mostly just to scare them off, but one needed a couple finishers after a 12 gauge Brenneke broke him down. The 12 slug was stopped; the Colt 300s weren't. One winter a caribou was a meat opportunity along the trail so I zipped back for the carbine. The shot, around 200 yards (with some good elevation), struck a shovel, drilled the shoulder and exited in front of the hip opposite. That bull was pushing 400 pounds. They're adequate tools.