I had a Marlin 1894 loaded with the 250 grain Speer Deep Curl. Was using Lil Gun and getting 1,800 fps. The recoil was a bit tough. I finally settled on the 240 gr Hornady at 1,700 fps. These are rifle loads, so I wouldn't use the full power loads out of a older single action handgun.

This evening I took a large doe at 100 yards with a Henry All Weather in .45 Colt. I'm using the 225 gr Barnes XPB at 1,620 fps.

Was hoping to drill the shoulders, but she was at a slight angle and double lunged her. Missed the shoulder, she dashed for 45-50 yards into a swamp. Good blood trail with a 1 1/2" hole through both sides of the rib cage. No blood shot meat at all.