I had the first LH 375 Ruger Guide Gun that rolled off the line. At least that's what the factory told me. It would regularly shoot Nosler 260 Partition bullets under 2" @ 300yds with a case full of Varget.

I took a buffalo at about 125yds with that load. He took two shots directly behind the shoulder before he decided to fall over. Both bullets were recovered in the off-side hide. They looked like they came right out of Nosler's catalog. The Barnes 270TSX was also a good shooter in my rifle.