I've seen em shot with a 25/06, 7 RM, 300 Win, 338, 340 300 Wby and a bow and a 45/70.
They had this in common.
The lung shot critters died in about 3 minutes with a rifle and with the bow it took 13 minutes (and yes I did actually time these).
The ones shot in the neck died right pronto if the neck was broken.
IMO and IME it don't matter tons, take the break the neck and it is over. Hit them in the lungs and then pour yourself a cup of coffee and wait till they tip over.
Dober
