A 300 grain hard cast bullet in a 45 Colt handgun at 1070 has an established reputation of being a big game load. I'd stick with hard cast flatnose for big game where penetration is most important. The XTP will give moderate expansion on medium game and make it a better choice for larger wound channels. I think the 45 Colt is about the best choice for subsonic suppressed hunting. I wish you could get it in a bolt action rifle though the Henry is a fine lever gun.
