Long ago Layne Simpson wrote that he thought the 257 Roberts and 338 Win Mag were enough of a versatile pair that a guy would be well equipped to handle all North American hunting. I don't think he was wrong.

I personally think that with a fast twist 223 the lines of performance are blurred quite a bit. I like quarterbore rifles, and think a 25-06 is about perfect middle size rifle. For large I chose a 338WM.

These days, I'd probably get a 6.5 or 7mm PRC and call it good, just because they're currently popular and reloading brass is easy to get. If you really must go bigger for some reason I still think the 338WM is a fine choice.

Sadly many of the truly great options are fading from popularity and getting hard to get brass or factory ammo for.

“You never need fear a man, no matter what his size. When danger threatens, call on me, and I will equalize.”
Samuel Colt.

�Common sense is genius dressed up in work clothes.� - Ralph Waldo Emerson