Centershot, I've chrono'd a .45 Colt load that will shoot through a deer if I shoot accurately.
255 grains SWC gas checked Keith type bullet, 8.5 grains Unique, WW Large Pistol Primers. Starline brass = 955 F.P.S., from my Ruger Blackhawk, 4 5/8" barrel.
If I wanted a faster load, I'd kick the Unique up to 10.0 grains, which would chronograph at around 1050 F.P.S., but the load I listed is fine with me. Easy to shoot and not hard on the wrist so makes it pleasant to do a lot of practicing.
It'll handle what I need out in the field.
Good luck on your hunt.
L.W.