This is my favorite hunting load for my 45 Colt, a Bowen customized Ruger Bisley with a 5.5" barrel. I have not killed any deer with it, yet, but it works well on feral hogs. For hunting I favor hard cast bullets.

270 gr Leadheads Keith style Taylor KO 22.15
19.5 gr 2400
WLP primer
1270 fps

"When there's lead in the air, there's hope in the heart."
Patron Member, NRA
Life Member, SCI
Life Member, Whittington Center
SASS member
Life Member, National Federation of Poachers