Yep you can fireform the .375 cases in a 375 Wby..I have seen probably 40 buffalo killed with the equivelent of a .375 Wby by Saeed of AR fame....He really knocks them down with his 375/404 and the two are equal for all practical purposes. The fast 375s are pretty impressive with good bullets..The are fast enough to probably best be used with monolithic hollow points.