It only has two negatives when compared to the 375.
1) Dies are not as readily available and depending on brand are more costly. I think they are Group G with RCBS.
2) In the case of top end custom wood gun on something like a M98 or M70 I think resale value would take a dive if 375 Wby was on the barrel instead of 375 H&H
If you search on AR's Big Bore forum there is heaps of stuff.